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ACS Nano. 2015 Dec 22;9(12):12174-81. doi: 10.1021/acsnano.5b05325. Epub 2015 Oct 29.

Printable Ultrathin Metal Oxide Semiconductor-Based Conformal Biosensors.

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California NanoSystems Institute, ‡Department of Materials Science and Engineering, §Department of Pharmacology, ∥Department of Chemistry and Biochemistry, and ⊥Department of Psychiatry, Hatos Center for Neuropharmacology, and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles , Los Angeles, California 90095, United States.


Conformal bioelectronics enable wearable, noninvasive, and health-monitoring platforms. We demonstrate a simple and straightforward method for producing thin, sensitive In2O3-based conformal biosensors based on field-effect transistors using facile solution-based processing. One-step coating via aqueous In2O3 solution resulted in ultrathin (3.5 nm), high-density, uniform films over large areas. Conformal In2O3-based biosensors on ultrathin polyimide films displayed good device performance, low mechanical stress, and highly conformal contact determined using polydimethylsiloxane artificial skin having complex curvilinear surfaces or an artificial eye. Immobilized In2O3 field-effect transistors with self-assembled monolayers of NH2-terminated silanes functioned as pH sensors. Functionalization with glucose oxidase enabled d-glucose detection at physiologically relevant levels. The conformal ultrathin field-effect transistor biosensors developed here offer new opportunities for future wearable human technologies.


aqueous process; biosensor; conformal; field-effect transistor; flexible; metal oxide semiconductor

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