Format

Send to

Choose Destination
Trends Microbiol. 2015 Dec;23(12):812-821. doi: 10.1016/j.tim.2015.09.007. Epub 2015 Oct 20.

Brucella abortus Cell Cycle and Infection Are Coordinated.

Author information

1
University of Namur, 61 rue de Bruxelles, 5000 Namur, Belgium. Electronic address: xavier.debolle@unamur.be.
2
University of Chicago, Gordon Center for Integrative Science W125, 929 E. 57th Street, Chicago, IL 60637, USA.
3
University of Namur, 61 rue de Bruxelles, 5000 Namur, Belgium.

Abstract

Brucellae are facultative intracellular pathogens. The recent development of methods and genetically engineered strains allowed the description of cell-cycle progression of Brucella abortus, including unipolar growth and the ordered initiation of chromosomal replication. B. abortus cell-cycle progression is coordinated with intracellular trafficking in the endosomal compartments. Bacteria are first blocked at the G1 stage, growth and chromosome replication being resumed shortly before reaching the intracellular proliferation compartment. The control mechanisms of cell cycle are similar to those reported for the bacterium Caulobacter crescentus, and they are crucial for survival in the host cell. The development of single-cell analyses could also be applied to other bacterial pathogens to investigate their cell-cycle progression during infection.

KEYWORDS:

Brucella; cell cycle; growth; intracellular infection; replication

PMID:
26497941
DOI:
10.1016/j.tim.2015.09.007
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center