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Immunol Rev. 2015 Nov;268(1):288-95. doi: 10.1111/imr.12345.

Immune regulation by Fcα/μ receptor (CD351) on marginal zone B cells and follicular dendritic cells.

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Department of Immunology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
Department of Immunology, Life Science Center of Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Ibaraki, Japan.
Department of Immunology, Japan Science and Technology Agency, Core Research for Evolutional Science and Technology (CREST), University of Tsukuba, Ibaraki, Japan.


Although both Fcα/μ receptor (Fcα/μR) and polymeric Ig receptor (poly-IgR) are Fc receptors for IgA and IgM and are functionally and genetically related, the expression profile of Fcα/μR is unique. Unlike poly-IgR, Fcα/μR is expressed on marginal zone (MZ) B cells and follicular dendritic cells, suggesting that Fcα/μR plays an important role in humoral immune responses. Fcα/μR mediates endocytosis of the IgM immune complex (IC). Recent research demonstrated that Fcα/μR downregulated retention of the IgM IC with a T-independent (TI) antigen on MZ B cells and follicular dendritic cells due to endocytosis of the IgM IC, suppressing germinal center formation, affinity maturation, and memory B-cell generation in response to TI antigen challenge. In addition, Fcα/μR physically associates with Toll-like receptor 4 (TLR4) and augments TLR4 oligomerization and signaling in MZ B cells upon lipopolysaccharide (LPS) challenge, leading to increased proinflammatory cytokine production by MZ B cells. Thus, Fcα/μR is a unique Fc receptor that is involved in humoral immune responses and inflammation.


Fc receptor; Fcα/μ receptor; IgA; IgM; follicular dendritic cells; marginal zone B cells

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