Evolutionary reprograming of protein-protein interaction specificity

Cell. 2015 Oct 22;163(3):535-7. doi: 10.1016/j.cell.2015.10.010. Epub 2015 Oct 22.

Abstract

Using mutation libraries and deep sequencing, Aakre et al. study the evolution of protein-protein interactions using a toxin-antitoxin model. The results indicate probable trajectories via "intermediate" proteins that are promiscuous, thus avoiding transitions via non-interactions. These results extend observations about other biological interactions and enzyme evolution, suggesting broadly general principles.

Publication types

  • Comment

MeSH terms

  • Evolution, Molecular*
  • Mesorhizobium / metabolism*
  • Protein Interaction Maps*