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Cell. 2015 Oct 22;163(3):535-7. doi: 10.1016/j.cell.2015.10.010. Epub 2015 Oct 22.

Evolutionary reprograming of protein-protein interaction specificity.

Author information

1
Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94158, USA.
2
Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Pharmaceutical Chemistry, and California Institute for Quantitative Biosciences, University of California, San Francisco, SanĀ Francisco, CA 94158, USA. Electronic address: babbitt@cgl.ucsf.edu.

Abstract

Using mutation libraries and deep sequencing, Aakre etĀ al. study the evolution of protein-protein interactions using a toxin-antitoxin model. The results indicate probable trajectories via "intermediate" proteins that are promiscuous, thus avoiding transitions via non-interactions. These results extend observations about other biological interactions and enzyme evolution, suggesting broadly general principles.

PMID:
26496596
DOI:
10.1016/j.cell.2015.10.010
[Indexed for MEDLINE]
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