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Cell. 2015 Oct 22;163(3):534-5. doi: 10.1016/j.cell.2015.10.033. Epub 2015 Oct 22.

Much ado about zero.

Author information

1
Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, New York University Langone School of Medicine, New York, NY 10016, USA. Electronic address: jef.boeke@nyumc.org.
2
Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, New York University Langone School of Medicine, New York, NY 10016, USA.

Abstract

LINE retrotransposons actively shape mammalian genomes. Denli et al. reveal a new open reading frame, ORF0, on the antisense strand of human LINE-1 encoding a small regulatory protein. This finding may represent the birth of an emerging retrotransposon gene that can adopt various fates, as it can be fused to adjacent host sequences.

PMID:
26496595
DOI:
10.1016/j.cell.2015.10.033
[Indexed for MEDLINE]
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