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PLoS One. 2015 Oct 23;10(10):e0141015. doi: 10.1371/journal.pone.0141015. eCollection 2015.

A Randomized Controlled Trial of the Use of Oral Glucose with or without Gentle Facilitated Tucking of Infants during Neonatal Echocardiography.

Author information

1
Children's & Women's Health Centre of British Columbia, Vancouver, Canada; Department of Pediatrics/Division of Neonatology, University of British Columbia, Vancouver, Canada; Child & Family Research Institute, Vancouver, Canada.
2
Children's & Women's Health Centre of British Columbia, Vancouver, Canada; Department of Pediatrics/Division of Neonatology, University of British Columbia, Vancouver, Canada.
3
Department of Pediatrics/Division of Neonatology, University of Toronto, Ontario, Canada.
4
Department of Pharmacy, Children's & Women's Health Centre of British Columbia, Vancouver, Canada.
5
Children's & Women's Health Centre of British Columbia, Vancouver, Canada.
6
Children's & Women's Health Centre of British Columbia, Vancouver, Canada; Department of Pediatrics/Division of Cardiology, University of British Columbia, Vancouver, Canada.
7
Child & Family Research Institute, Vancouver, Canada; Department of Statistics, University of British Columbia, Vancouver, Canada.
8
Child & Family Research Institute, Vancouver, Canada; Department of Occupational Science and Occupational Therapy, University of British Columbia, Vancouver, Canada.

Abstract

OBJECTIVE:

To compare the effect of oral glucose given with or without facilitated tucking (FT), versus placebo (water) to facilitate image acquisition during a targeted neonatal echocardiography (TNE).

DESIGN:

Factorial, double blind, randomized controlled trial.

SETTING:

Tertiary neonatal intensive care unit (NICU).

PATIENTS:

Infants born between 26 and 42 weeks of gestation (GA).

INTERVENTIONS:

One of four treatment groups: oral water (placebo), oral glucose (25%), facilitated tucking with oral water or facilitated tucking with oral glucose, during a single, structured TNE. All infants received a soother.

MAIN OUTCOME MEASURE:

Change in Behavioral Indicators of Infant Pain (BIIP) scores.

RESULTS:

104 preterm infants were randomized (mean ± SD GA: 33.4 ± 3.5 weeks). BIIP scores remained low during the echocardiography scan (median, [IQ range]: 0, [0 to 1]). There were no differences in the level of agitation of infants amongst the treatment groups, with estimated reductions in mean BIIP relative to control of 0.27 (95%CI -0.40 to 0.94) with use of oral glucose and .04 (-0.63 to 0.70) with facilitated tucking. There were also no differences between treatment groups in the quality and duration of the echocardiography scans.

CONCLUSIONS:

In stable infants in the NICU, a TNE can be performed with minimal disruption in a majority of cases, simply by providing a soother. The use of 25% glucose water in this context did not provide further benefit in reducing agitation and improving image acquisition.

CLINICAL TRIAL REGISTRATION:

Clinical Trials.gov: NCT01253889.

PMID:
26496361
PMCID:
PMC4619855
DOI:
10.1371/journal.pone.0141015
[Indexed for MEDLINE]
Free PMC Article

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