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Oncotarget. 2015 Nov 3;6(34):35395-403. doi: 10.18632/oncotarget.6173.

Association between serum uric acid and bone health in general population: a large and multicentre study.

Author information

1
Department of Orthopedics Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, China.
2
Department of Orthopedics, Shanghai Key Laboratory of Orthopedic Implant, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
3
Department of Orthopedics Surgery, Taizhou Hospital of Wenzhou Medical University, Linhai, China.
4
Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
5
Department of Cardiology, The Key Laboratory of Cardiovascular Disease of Wenzhou, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Abstract

Previous studies proposed that serum uric acid (UA), an endogenous antioxidant, could be a protective factor against bone loss. However, recently, a study with a population of US adults did not note the protective effects of serum UA. Therefore, the exact association between serum UA and bone health remains unclear. We performed a retrospective consecutive cohort study in a Chinese population to examine the association between serum UA and bone health. This cross-sectional study included 17,735 individuals who underwent lumbar spine bone mineral density (BMD) measurements as part of a health examination. In covariance analyses (multivariable-adjusted), a high serum UA level was associated with a high BMD, T-score, and Z-score. In binary logistic regression analyses (multivariable-adjusted), a high serum UA level was associated with low odds ratios (ORs) for at least osteopenia and osteoporosis in male (age ≥50 years) (OR = 0.72-0.60 and OR = 0.49-0.39, respectively) and postmenopausal female participants (OR = 0.61-0.51 and OR = 0.66-0.49, respectively). In conclusion, serum UA is associated with BMD, the T-score, and the Z-score, and has a strong protective effect against at least osteopenia and osteoporosis.

KEYWORDS:

DXA; Gerotarget; bone health; bone mass loss; bone mineral density; serum uric acid

PMID:
26496032
PMCID:
PMC4742113
DOI:
10.18632/oncotarget.6173
[Indexed for MEDLINE]
Free PMC Article

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