Format

Send to

Choose Destination
Angew Chem Int Ed Engl. 2015 Dec 7;54(50):15152-5. doi: 10.1002/anie.201507140. Epub 2015 Oct 23.

A Multifunctional Subphthalocyanine Nanosphere for Targeting, Labeling, and Killing of Antibiotic-Resistant Bacteria.

Author information

1
Center for Self-assembly and Complexity (CSC), Institute for Basic Science (IBS), Pohang, 790-784 (Republic of Korea) http://csc.ibs.re.kr/
2
Department of Chemistry, Pohang University of Science and Technology, Pohang, 790-784 (Republic of Korea).
3
Department of Creative IT Engineering and Electrical Engineering, Pohang University of Science and Technology, Pohang, 790-784 (Republic of Korea).
4
Center for Self-assembly and Complexity (CSC), Institute for Basic Science (IBS), Pohang, 790-784 (Republic of Korea) http://csc.ibs.re.kr/. kkim@postech.ac.kr.
5
Department of Chemistry, Pohang University of Science and Technology, Pohang, 790-784 (Republic of Korea). kkim@postech.ac.kr.
6
Division of Advanced Materials Science, Pohang University of Science and Technology, Pohang, 790-784 (Republic of Korea). kkim@postech.ac.kr.

Abstract

Developing a material that can combat antibiotic-resistant bacteria, a major global health threat, is an urgent requirement. To tackle this challenge, we synthesized a multifunctional subphthalocyanine (SubPc) polymer nanosphere that has the ability to target, label, and photoinactivate antibiotic-resistant bacteria in a single treatment with more than 99 % efficiency, even with a dose as low as 4.2 J cm(-2) and a loading concentration of 10 nM. The positively charged nanosphere shell composed of covalently linked SubPc units can increase the local concentration of photosensitizers at therapeutic sites. The nanosphere shows superior performance compared to corresponding monomers presumably because of their enhanced water dispersibility, higher efficiency of singlet-oxygen generation, and phototoxicity. In addition, this material is useful in fluorescence labeling of living cells and shows promise in photoacoustic imaging of bacteria in vivo.

KEYWORDS:

antibiotic resistance; nanostructures; photodynamic therapy; self-assembly; subphthalocyanines

PMID:
26493283
DOI:
10.1002/anie.201507140
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center