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Schizophr Res. 2016 Jan;170(1):137-42. doi: 10.1016/j.schres.2015.10.017. Epub 2015 Oct 20.

Motor behavior reflects reduced hemispheric asymmetry in the psychosis risk period.

Author information

1
University of Colorado Boulder, Department of Psychology and Neuroscience, United States; University of Colorado Boulder, Center for Neuroscience, United States. Electronic address: derek.dean@colorado.edu.
2
Texas A&M University, Department of Psychology, United States.
3
University of Colorado Boulder, Department of Psychology and Neuroscience, United States.
4
Northwestern University, Department of Psychology, United States.

Abstract

BACKGROUND:

A body of work focusing on brain connectivity, language dominance, and motor laterality research suggests that reduced hemispheric asymmetry is a core feature in schizophrenia. However, there is little consensus about whether reduced dominance is present in those at ultrahigh risk (UHR) for psychosis.

METHODS:

A total of 94 demonstrated right-handed neuroleptic free participants (38 UHR and 56 matched healthy controls) were assessed with structured clinical interviews and completed an innovative handwriting task using a digital tablet computer. A laterality quotient (LQ) was calculated using kinematic variables from the participant's left and right hands. A subset of the sample (26 UHR and 29 controls) returned after 12-months to complete clinical interviews in order to examine relationships between handwriting laterality and progression of psychosis risk symptoms.

RESULTS:

The UHR group showed decreased dextrality compared to healthy controls. At the 12-month follow-up, decreased dextrality accounted for 8% of the variance in worsened positive symptoms within the UHR group.

CONCLUSION:

The current results suggest that disrupted cerebral dominance is also present in the ultrahigh risk period and that decreased dextrality may serve as a novel biomarker for the progression of psychosis risk.

KEYWORDS:

Cerebral dominance; Dextrality; Handwriting; Laterality; Psychosis; Ultrahigh risk

PMID:
26492987
PMCID:
PMC4707112
DOI:
10.1016/j.schres.2015.10.017
[Indexed for MEDLINE]
Free PMC Article

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