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Cold Spring Harb Perspect Biol. 2016 Nov 1;8(11). pii: a019463. doi: 10.1101/cshperspect.a019463.

Metabolic Signaling to Chromatin.

Author information

1
Department of Cell & Developmental Biology, Department of Biology, and Department of Genetics, Epigenetics Program, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6508.
2
Center for Epigenetics and Metabolism, Department of Biological Chemistry, University of California, Irvine, Irvine, California 92697-4049.

Abstract

There is a dynamic interplay between metabolic processes and gene regulation via the remodeling of chromatin. Most chromatin-modifying enzymes use cofactors, which are products of metabolic processes. This article explores the biosynthetic pathways of the cofactors nicotinamide adenine dinucleotide (NAD), acetyl coenzyme A (acetyl-CoA), S-adenosyl methionine (SAM), α-ketoglutarate, and flavin adenine dinucleotide (FAD), and their role in metabolically regulating chromatin processes. A more detailed look at the interaction between chromatin and the metabolic processes of circadian rhythms and aging is described as a paradigm for this emerging interdisciplinary field.

PMID:
26492570
PMCID:
PMC5088527
DOI:
10.1101/cshperspect.a019463
[Indexed for MEDLINE]
Free PMC Article

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