Format

Send to

Choose Destination
Nat Rev Mol Cell Biol. 2015 Nov;16(11):678-89. doi: 10.1038/nrm4074.

Transcriptional regulation of hepatic lipogenesis.

Author information

1
Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California 94720, USA.

Erratum in

  • Nat Rev Mol Cell Biol. 2016 Jan;17(1):64.

Abstract

Fatty acid and fat synthesis in the liver is a highly regulated metabolic pathway that is important for very low-density lipoprotein (VLDL) production and thus energy distribution to other tissues. Having common features at their promoter regions, lipogenic genes are coordinately regulated at the transcriptional level. Transcription factors, such as upstream stimulatory factors (USFs), sterol regulatory element-binding protein 1C (SREBP1C), liver X receptors (LXRs) and carbohydrate-responsive element-binding protein (ChREBP) have crucial roles in this process. Recently, insights have been gained into the signalling pathways that regulate these transcription factors. After feeding, high blood glucose and insulin levels activate lipogenic genes through several pathways, including the DNA-dependent protein kinase (DNA-PK), atypical protein kinase C (aPKC) and AKT-mTOR pathways. These pathways control the post-translational modifications of transcription factors and co-regulators, such as phosphorylation, acetylation or ubiquitylation, that affect their function, stability and/or localization. Dysregulation of lipogenesis can contribute to hepatosteatosis, which is associated with obesity and insulin resistance.

PMID:
26490400
PMCID:
PMC4884795
DOI:
10.1038/nrm4074
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center