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Immunity. 2015 Oct 20;43(4):634-45. doi: 10.1016/j.immuni.2015.09.013.

Natural Killer Cell Memory.

Author information

1
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
2
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA; Department of Immunology and Microbial Pathogenesis, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address: sunj@mskcc.org.
3
Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: lewis.lanier@ucsf.edu.

Abstract

Natural killer (NK) cells have historically been considered short-lived cytolytic cells that can rapidly respond against pathogens and tumors in an antigen-independent manner and then undergo cell death. Recently, however, NK cells have been shown to possess traits of adaptive immunity and can acquire immunological memory in a manner similar to that of T and B cells. In this review, we discuss evidence of NK cell memory and the mechanisms involved in the generation and survival of these innate lymphocytes.

KEYWORDS:

cytomegalovirus; immunological memory; natural killer cells

PMID:
26488815
PMCID:
PMC4621966
DOI:
10.1016/j.immuni.2015.09.013
[Indexed for MEDLINE]
Free PMC Article

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