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Immunity. 2015 Oct 20;43(4):624-6. doi: 10.1016/j.immuni.2015.10.003.

Keeping Off the Weight with DCs.

Author information

1
Department of Medicine, Naomi Berrie Diabetes Center, Columbia University, 1150 St Nicholas Ave, New York, NY 10032, USA.
2
Department of Medicine, Naomi Berrie Diabetes Center, Columbia University, 1150 St Nicholas Ave, New York, NY 10032, USA. Electronic address: awf7@cumc.columbia.edu.

Abstract

Long studied as modulators of insulin sensitivity, adipose tissue immune cells have recently been implicated in regulating fat mass and weight gain. In this issue of Immunity, Reisner and colleagues (2015) report that ablation of perforin-expressing dendritic cells induces T cell expansion, worsening autoimmunity and surprisingly increasing adiposity.

PMID:
26488811
DOI:
10.1016/j.immuni.2015.10.003
[Indexed for MEDLINE]
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