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J Wound Care. 2015 Oct;24(10):459-60, 462-5. doi: 10.12968/jowc.2015.24.10.459.

Comparative trial of Aloe vera/olive oil combination cream versus phenytoin cream in the treatment of chronic wounds.

Author information

1
Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
2
Health Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
3
Pharmaceutical Consultant, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran.
4
Department of Physiology and Pharmacology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.
5
Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
6
Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
7
Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia.

Abstract

OBJECTIVE:

Aloe vera is a medicinal plant that has been traditionally used to accelerate wound healing. Olive oil is also a natural product that may contribute to wound healing owing to its antimicrobial and anti-inflammatory effects. The present study aimed to evaluate the effect of an Aloe vera-olive oil (AVO) combination cream on the healing process of chronic wounds.

METHOD:

In this randomised, double-blind, comparator-controlled, parallel-group trial, patients with chronic wounds were treated with either AVO cream or phenytoin cream as the standard treatment for a period of 30 days. Wound healing was evaluated using Bates-Jensen assessment tool and the severity of pain was assessed using a visual analogue scale (VAS).

RESULTS:

After initial assessment, 60 patients with chronic wounds (41 with pressure ulcer, 13 with diabetic wounds and 6 with venous ulcers), were recruited and randomised into 2 groups of 30. After 30 days of treatment, significant improvements in the wound size, depth, and edges; necrotic tissue type and amount; exudate type and amount; colour of wound surroundings; and peripheral tissue oedema score were observed in the AVO cream group (p<0.001). The total score of wound healing showed significant improvement with both AVO (p<0.001) and phenytoin (p<0.01) creams, although AVO was more efficacious (p<0.001). Likewise, although both treatments reduced the initial VAS score, the efficacy of AVO was significantly greater (p<0.001).

CONCLUSION:

AVO cream significantly accelerates biological healing of chronic wounds and helps to reduce pain severity with a higher efficacy compared with phenytoin cream.

KEYWORDS:

Aloe vera; olive oil; randomised controlled trial; skin; wound

Comment in

PMID:
26488737
DOI:
10.12968/jowc.2015.24.10.459
[Indexed for MEDLINE]

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