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Ther Deliv. 2015;6(8):989-1016. doi: 10.4155/tde.15.48. Epub 2015 Aug 25.

Promising approaches to circumvent the blood-brain barrier: progress, pitfalls and clinical prospects in brain cancer.

Author information

1
Department of Mechanical Engineering, Boston University, Boston, MA 02215, USA.
2
Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
3
Center for Nanoscience & Nanobiotechnology, Boston University, Boston, MA 02215, USA.

Abstract

Brain drug delivery is a major challenge for therapy of central nervous system (CNS) diseases. Biochemical modifications of drugs or drug nanocarriers, methods of local delivery, and blood-brain barrier (BBB) disruption with focused ultrasound and microbubbles are promising approaches which enhance transport or bypass the BBB. These approaches are discussed in the context of brain cancer as an example in CNS drug development. Targeting to receptors enabling transport across the BBB offers noninvasive delivery of small molecule and biological cancer therapeutics. Local delivery methods enable high dose delivery while avoiding systemic exposure. BBB disruption with focused ultrasound and microbubbles offers local and noninvasive treatment. Clinical trials show the prospects of these technologies and point to challenges for the future.

PMID:
26488496
PMCID:
PMC4618388
DOI:
10.4155/tde.15.48
[Indexed for MEDLINE]
Free PMC Article

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