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World J Clin Cases. 2015 Oct 16;3(10):920-5. doi: 10.12998/wjcc.v3.i10.920.

Repeated pancreatitis-induced splenic vein thrombosis leads to intractable gastric variceal bleeding: A case report and review.

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Shan-Hong Tang, Wei-Zheng Zeng, Jian-Ping Qin, Xiao-Ling Wu, Zhao Wang, Xuan He, Xiao-Lei Zhou, Ming-De Jiang, Department of Digestion, General Hospital of Chengdu Military Command, Chengdu 610083, Sichuan Province, China.


Gastric varices (GV) are one of the most common complications for patients with portal hypertension. Currently, histoacryl injection is recommended as the initial treatment for bleeding of GV, and this injection has been confirmed to be highly effective for most patients in many studies. However, this treatment might be ineffective for some types of GV, such as splenic vein thrombosis-related localized portal hypertension (also called left-sided, sinistral, or regional portal hypertension). Herein, we report a case of repeated pancreatitis-induced complete splenic vein thrombosis that led to intractable gastric variceal bleeding, which was treated by splenectomy. We present detailed radiological and pathological data and blood rheology analysis (the splenic artery - after a short gastric vein or stomach vein - gastric coronary vein - portal vein). The pathophysiology can be explained by the abnormal direction of blood flow in this patient. To our knowledge, this is the first reported case for which detailed pathology and blood rheology data are available.


Intractable gastric variceal bleeding; Recurrent pancreatitis; Review; Splenic vein thrombosis

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