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Cell Res. 2015 Nov;25(11):1183-4. doi: 10.1038/cr.2015.124. Epub 2015 Oct 20.

Gasdermin D: the long-awaited executioner of pyroptosis.

Author information

1
Department of Immunology, St. Jude Children's Research Hospital, MS #351, 262 Danny Thomas Place, Memphis, TN 38105, USA.

Abstract

Inflammatory caspases drive a lytic form of cell death called pyroptosis in response to microbial infection and endogenous damage-associated signals. Two studies now demonstrate that cleavage of the substrate gasdermin D by inflammatory caspases necessitates eventual pyroptotic demise of a cell.

PMID:
26482951
PMCID:
PMC4650426
DOI:
10.1038/cr.2015.124
[Indexed for MEDLINE]
Free PMC Article

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