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Bioresour Technol. 2016 Jan;199:103-112. doi: 10.1016/j.biortech.2015.10.009. Epub 2015 Oct 13.

Pretreatment of lignocellulose: Formation of inhibitory by-products and strategies for minimizing their effects.

Author information

1
Department of Chemistry, Umeå University, SE-901 87 Umeå, Sweden. Electronic address: leif.jonsson@chem.umu.se.
2
Department of Chemistry, Umeå University, SE-901 87 Umeå, Sweden.

Abstract

Biochemical conversion of lignocellulosic feedstocks to advanced biofuels and other commodities through a sugar-platform process involves a pretreatment step enhancing the susceptibility of the cellulose to enzymatic hydrolysis. A side effect of pretreatment is formation of lignocellulose-derived by-products that inhibit microbial and enzymatic biocatalysts. This review provides an overview of the formation of inhibitory by-products from lignocellulosic feedstocks as a consequence of using different pretreatment methods and feedstocks as well as an overview of different strategies used to alleviate problems with inhibitors. As technologies for biorefining of lignocellulose become mature and are transferred from laboratory environments to industrial contexts, the importance of management of inhibition problems is envisaged to increase as issues that become increasingly relevant will include the possibility to use recalcitrant feedstocks, obtaining high product yields and high productivity, minimizing the charges of enzymes and microorganisms, and using high solids loadings to obtain high product titers.

KEYWORDS:

Biorefining; Detoxification; Inhibitors; Lignocellulose; Pretreatment

PMID:
26482946
DOI:
10.1016/j.biortech.2015.10.009
[Indexed for MEDLINE]
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