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Pediatr Clin North Am. 1989 Apr;36(2):281-310.

Controversies concerning neonatal seizures.

Author information

1
University of Pittsburgh School of Medicine, Pennsylvania.

Abstract

Five issues are discussed with respect to the diagnosis, etiology, treatment, prognosis, and pathogenesis of neonatal seizures. The presentation of a newborn with seizures represents a true emergency and frequently indicates significant neurologic dysfunction or damage to the immature nervous system. Despite the urgency to establish a diagnosis, several unique aspects of neonatal seizures impede prompt recognition. In addition, several etiologic possibilities may be associated with seizures. The efficacy of antiepileptic drugs and the prediction of outcome of patients with neonatal seizures are controversial. Experimental research in developing animals suggests both a selective vulnerability and resistance of the brains of immature animals subjected to neonatal seizures.

PMID:
2648280
DOI:
10.1016/s0031-3955(16)36650-0
[Indexed for MEDLINE]

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