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Genome Med. 2015 Oct 20;7:106. doi: 10.1186/s13073-015-0232-5.

The age factor in Alzheimer's disease.

Author information

1
Department of Molecular Neuroscience, Institute of Neurology, University College London, 1 Wakefield Street, London, WC1N 1PJ, UK. r.guerreiro@ucl.ac.uk.
2
Department of Molecular Neuroscience, Institute of Neurology, University College London, 1 Wakefield Street, London, WC1N 1PJ, UK.

Abstract

Alzheimer's disease is the most common type of dementia, and it is characterized by a decline in memory or other thinking skills. The greatest risk factor for Alzheimer's disease is advanced age. A recent genome-wide study identified a locus on chromosome 17 associated with the age at onset, and a specific variant in CCL11 is probably responsible for the association. The association of a protective haplotype with a 10-year delay in the onset of Alzheimer's disease and the identification of a CCL11 variant with possible functional roles in this association might allow the future development of immunomodulators with the potential to halve disease incidence.

PMID:
26482651
PMCID:
PMC4617238
DOI:
10.1186/s13073-015-0232-5
[Indexed for MEDLINE]
Free PMC Article

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