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Trends Microbiol. 2015 Dec;23(12):799-811. doi: 10.1016/j.tim.2015.09.006. Epub 2015 Oct 17.

Pentraxins and Collectins: Friend or Foe during Pathogen Invasion?

Author information

1
Institute for Glycomics, Griffith University, Gold Coast, QLD 4222, Australia.
2
WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria 3000, Australia.
3
Humanitas Clinical and Research Center, Department of Inflammation and Immunology, 20089, Rozzano, Milano, Italy.
4
Humanitas Clinical and Research Center, Department of Inflammation and Immunology, 20089, Rozzano, Milano, Italy; Humanitas University, 20089, Rozzano, Milano, Italy.
5
Institute for Glycomics, Griffith University, Gold Coast, QLD 4222, Australia. Electronic address: s.mahalingam@griffith.edu.au.

Abstract

Innate immunity serves as the frontline defence against invading pathogens. Despite decades of research, new insights are constantly challenging our understanding of host-elicited immunity during microbial infections. Recently, two families of humoral innate immune proteins, pentraxins and collectins, have become a major focus of research in the field of innate immunity. Pentraxins and collectins are key players in activating the humoral arm of innate immunity, taking centre stage in immunoregulation and disease modulation. However, increasing evidence suggests that pentraxins and collectins can also mediate pathogenic effects during some infections. Herein, we discuss the protective and pathogenic effects of pentraxins and collectins, as well as their therapeutic significance.

KEYWORDS:

collectins; humoral innate immunity; mannose-binding lectin; pathogens; pentraxin 3; pentraxins

PMID:
26482345
DOI:
10.1016/j.tim.2015.09.006
[Indexed for MEDLINE]

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