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Antimicrob Agents Chemother. 2015 Oct 19;60(1):621-3. doi: 10.1128/AAC.01211-15. Print 2016 Jan.

Multidrug-Resistant Neisseria gonorrhoeae Isolates from Nanjing, China, Are Sensitive to Killing by a Novel DNA Gyrase Inhibitor, ETX0914 (AZD0914).

Author information

1
National Center for STD and Leprosy Control, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
2
National Center for STD and Leprosy Control, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China wangbx@ncstdlc.org.
3
Macrolide Pharmaceuticals, Lexington, Massachusetts, USA.
4
Entasis Therapeutics, Waltham, Massachusetts, USA.
5
Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

Abstract

We tested the activity of ETX0914 against 187 Neisseria gonorrhoeae isolates from men with urethritis in Nanjing, China, in 2013. The MIC50, MIC90, and MIC range for ETX0914 were 0.03 μg/ml, 0.06 μg/ml, and ≤0.002 to 0.125 μg/ml, respectively. All isolates were resistant to ciprofloxacin, and 36.9% (69/187) were resistant to azithromycin. Of the isolates, 46.5% were penicillinase-producing N. gonorrhoeae (PPNG), 36% were tetracycline-resistant N. gonorrhoeae (TRNG), and 13% (24 isolates) had an MIC of 0.125 μg/ml for ceftriaxone. ETX0914 may be an effective treatment option for gonorrhea.

PMID:
26482313
PMCID:
PMC4704236
DOI:
10.1128/AAC.01211-15
[Indexed for MEDLINE]
Free PMC Article

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