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Neuroimage. 2016 Jan 15;125:1063-78. doi: 10.1016/j.neuroimage.2015.10.019. Epub 2015 Oct 20.

An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging.

Author information

  • 1FMRIB Centre, Oxford, United Kingdom. Electronic address: jesper@fmrib.ox.ac.uk.
  • 2FMRIB Centre, Oxford, United Kingdom.

Abstract

In this paper we describe a method for retrospective estimation and correction of eddy current (EC)-induced distortions and subject movement in diffusion imaging. In addition a susceptibility-induced field can be supplied and will be incorporated into the calculations in a way that accurately reflects that the two fields (susceptibility- and EC-induced) behave differently in the presence of subject movement. The method is based on registering the individual volumes to a model free prediction of what each volume should look like, thereby enabling its use on high b-value data where the contrast is vastly different in different volumes. In addition we show that the linear EC-model commonly used is insufficient for the data used in the present paper (high spatial and angular resolution data acquired with Stejskal-Tanner gradients on a 3T Siemens Verio, a 3T Siemens Connectome Skyra or a 7T Siemens Magnetome scanner) and that a higher order model performs significantly better. The method is already in extensive practical use and is used by four major projects (the WU-UMinn HCP, the MGH HCP, the UK Biobank and the Whitehall studies) to correct for distortions and subject movement.

KEYWORDS:

Diffusion; Eddy current; Movement; Registration; Susceptibility

PMID:
26481672
PMCID:
PMC4692656
DOI:
10.1016/j.neuroimage.2015.10.019
[PubMed - indexed for MEDLINE]
Free PMC Article
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