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J Clin Endocrinol Metab. 2015 Dec;100(12):4648-53. doi: 10.1210/jc.2015-3078. Epub 2015 Oct 19.

No Association Between Transient Hypothyroxinemia of Prematurity and Neurodevelopmental Outcome in Young Adulthood.

Author information

1
Department of Pediatrics (J.J.H., J.I., J.R., M.J.J.F.), VU University Medical Center, 1007 MB Amsterdam, The Netherlands; and Netherlands Organization for Applied Scientific Research (S.M.v.d.P., P.H.V.), Child Health, 2316 ZL Leiden, The Netherlands.

Abstract

CONTEXT:

Transient hypothyroxinemia of prematurity (THoP) has been associated with neurodevelopmental impairment in infancy and childhood. It is not known whether these relations persist into adulthood.

OBJECTIVE:

The objective was to examine whether there is an effect of THoP on intelligence quotient (IQ) score and motor functioning at a young adult age.

DESIGN:

This study was part of the 19-year follow-up of the Project On Preterm and Small-for-gestational-age birth (POPS) cohort, which included infants born very preterm (ie, <32 wk) and/or with a very low birth weight (ie, <1500 g).

SETTING:

This was a multicenter study.

PATIENTS:

There were 398 19-year-old participants of the POPS cohort, of whom 120 had THoP.

EXPOSURE:

T4 concentrations were obtained through the national neonatal screening program for congenital hypothyroidism. THoP was defined as a total T4 concentration < -3 SD of the daily mean (approximately 60 nmol/L).

MAIN OUTCOME MEASURES:

Main outcome measures were IQ and motor functioning, measured with the digital Multicultural Capacities Test-Intermediate Level and a revised version of Touwen's examination of minor neurological dysfunction, respectively.

RESULTS:

THoP was not associated with IQ score (mean difference, 0 [95% confidence interval, -3.8 to 3.8] points) or motor function (mean difference, 0.6 [95% confidence interval, -1.3 to 2.5] points) after adjustment for demographic and perinatal characteristics.

CONCLUSIONS:

No associations between THoP and neurodevelopmental outcome at age 19 years were found.

PMID:
26480285
DOI:
10.1210/jc.2015-3078
[Indexed for MEDLINE]

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