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PLoS One. 2015 Oct 19;10(10):e0140333. doi: 10.1371/journal.pone.0140333. eCollection 2015.

Synaptic Efficacy as a Function of Ionotropic Receptor Distribution: A Computational Study.

Author information

1
Center for Neural Engineering, Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States of America.
2
Center for Neural Engineering, Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States of America; Rhenovia Pharma, Mulhouse, France.
3
Rhenovia Pharma, Mulhouse, France.
4
Rhenovia Pharma, Mulhouse, France; Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA, United States of America.

Abstract

Glutamatergic synapses are the most prevalent functional elements of information processing in the brain. Changes in pre-synaptic activity and in the function of various post-synaptic elements contribute to generate a large variety of synaptic responses. Previous studies have explored postsynaptic factors responsible for regulating synaptic strength variations, but have given far less importance to synaptic geometry, and more specifically to the subcellular distribution of ionotropic receptors. We analyzed the functional effects resulting from changing the subsynaptic localization of ionotropic receptors by using a hippocampal synaptic computational framework. The present study was performed using the EONS (Elementary Objects of the Nervous System) synaptic modeling platform, which was specifically developed to explore the roles of subsynaptic elements as well as their interactions, and that of synaptic geometry. More specifically, we determined the effects of changing the localization of ionotropic receptors relative to the presynaptic glutamate release site, on synaptic efficacy and its variations following single pulse and paired-pulse stimulation protocols. The results indicate that changes in synaptic geometry do have consequences on synaptic efficacy and its dynamics.

PMID:
26480028
PMCID:
PMC4610697
DOI:
10.1371/journal.pone.0140333
[Indexed for MEDLINE]
Free PMC Article
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