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Rev Med Virol. 2015 Nov;25(6):431-45. doi: 10.1002/rmv.1858. Epub 2015 Oct 19.

Resveratrol, sirtuins, and viruses.

Author information

1
College of Food Science and Technology, Central South University of Forestry and Technology, Changsha, Hunan Province, China.
2
Construction Corps Key Laboratory of Deep Processing on Featured Agricultural Products in South Xinjiang, Tarim University, Alar, Xinjiang, China.
3
Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
4
Departments of Oral Pathology, College of Dentistry, Howard University, Washington, DC, USA.

Abstract

Resveratrol is a natural phenolic product found in some plants in response to stress and has been linked to the many health benefits of red wine. Over the past several decades, a great deal of research has identified diverse biological roles associated with resveratrol, including anti-oxidant, anti-proliferation, anti-inflammation, anti-cancer, anti-fungal, and antiviral activities. Such biological activities of resveratrol are likely mediated through multiple cellular targets or pathways, such as sirtuins, a family of NAD(+)-dependent deacetylases. In this treatise, the literatures focusing on the roles of resveratrol and sirtuins in modulating infections by a broad-spectrum of viruses are reviewed, with an emphasis on its potential antiviral mechanisms. A working model about the effects of resveratrol on virus infection is proposed to stimulate further researches on this exciting topic.

PMID:
26479742
DOI:
10.1002/rmv.1858
[Indexed for MEDLINE]

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