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Commun Integr Biol. 2015 Jun 22;8(3):e1040954. doi: 10.1080/19420889.2015.1040954. eCollection 2015 May-Jun.

Time-related expression profiles for heat shock protein gene transcripts (HSP40, HSP70) in the central nervous system of Lymnaea stagnalis exposed to thermal stress.

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School of Marine Science and Engineering; Plymouth University ; Drake Circus ; Plymouth, UK.
Hotchkiss Brain Institute; Cumming School of Medicine; University of Calgary ; Calgary, Canada.
School of Biomedical and Biological Sciences; Plymouth University ; Drake Circus ; Plymouth, UK ; Department of Forestry Wildlife and Fisheries, and Center for Environmental Biotechnology; The University of Tennessee ; Knoxville, TN USA ; Present address: School of Life Sciences; Heriot-Watt University ; Edinburgh, Scotland, UK.


Organisms exposed to environmental stressors respond by rapidly synthesising a suite of highly conserved proteins called heat shock proteins (HSPs). Environmental stress can also enhance and/or block memory formation, with long-term memory formation requiring gene activation and protein synthesis. Thermal stress in the pond snail Lymnaea stagnalis can enhance memory formation, and, in this study, the effect of thermal stress on HSP gene expression in the nervous system was investigated. Time-related expression profiles for HSP40 and HSP70 indicated rapid (<30 min) induction for both transcripts. For HSP40, induction was <20 fold relative to control and expression returned to control levels within 8 h, whereas HSP70 induction was >100 fold and expression did not return to control levels within 8 h.


environmental stress; gene expression; learning; long-term memory; pond snail

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