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Neuroimage. 2016 Jan 15;125:256-266. doi: 10.1016/j.neuroimage.2015.10.015. Epub 2015 Oct 20.

Structural and functional neuroplasticity in human learning of spatial routes.

Author information

1
Center for Cognitive Brain Imaging, Department of Psychology, Carnegie Mellon University, Pittsburgh, PA, USA. Electronic address: tk37@andrew.cmu.edu.
2
Center for Cognitive Brain Imaging, Department of Psychology, Carnegie Mellon University, Pittsburgh, PA, USA.

Abstract

Recent findings with both animals and humans suggest that decreases in microscopic movements of water in the hippocampus reflect short-term neuroplasticity resulting from learning. Here we examine whether such neuroplastic structural changes concurrently alter the functional connectivity between hippocampus and other regions involved in learning. We collected both diffusion-weighted images and fMRI data before and after humans performed a 45min spatial route-learning task. Relative to a control group with equal practice time, there was decreased diffusivity in the posterior-dorsal dentate gyrus of the left hippocampus in the route-learning group accompanied by increased synchronization of fMRI-measured BOLD signal between this region and cortical areas, and by changes in behavioral performance. These concurrent changes characterize the multidimensionality of neuroplasticity as it enables human spatial learning.

KEYWORDS:

Connectivity; DTI; Hippocampus; Neuroplasticity; Precuneus; Spatial learning; fMRI

[Indexed for MEDLINE]

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