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Nucleic Acids Res. 2016 Jan 4;44(D1):D1237-42. doi: 10.1093/nar/gkv1041. Epub 2015 Oct 17.

GlyTouCan 1.0--The international glycan structure repository.

Author information

1
Faculty of Science and Engineering, Soka University, Tokyo 192-8577, Japan Glycoscience and Glycotechnology Research Group, AIST, Ibaraki 305-8568, Japan kkiyoko@soka.ac.jp.
2
Department of Mathematics and Computer Science, Emory University, Atlanta, GA, 30322, USA.
3
Faculty of Science and Engineering, Soka University, Tokyo 192-8577, Japan.
4
Complex Carbohydrate Research Center, University of Georgia, Athens, GA, 30602, USA.
5
Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02115,USA.
6
Glycoscience and Glycotechnology Research Group, AIST, Ibaraki 305-8568, Japan.
7
Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
8
Department of Life Sciences, Faculty of National Sciences, Imperial College London, London, SW7 2AZ, UK.
9
Research Center for Glycobiotechnology, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan.
10
The Noguchi Institute, Tokyo 173-0003, Japan.
11
Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.
12
Center for Biomedical Mass Spectrometry, Dept. of Biochemistry, Boston University School of Medicine, Boston, MA, 02118, USA.

Abstract

Glycans are known as the third major class of biopolymers, next to DNA and proteins. They cover the surfaces of many cells, serving as the 'face' of cells, whereby other biomolecules and viruses interact. The structure of glycans, however, differs greatly from DNA and proteins in that they are branched, as opposed to linear sequences of amino acids or nucleotides. Therefore, the storage of glycan information in databases, let alone their curation, has been a difficult problem. This has caused many duplicated efforts when integration is attempted between different databases, making an international repository for glycan structures, where unique accession numbers are assigned to every identified glycan structure, necessary. As such, an international team of developers and glycobiologists have collaborated to develop this repository, called GlyTouCan and is available at http://glytoucan.org/, to provide a centralized resource for depositing glycan structures, compositions and topologies, and to retrieve accession numbers for each of these registered entries. This will thus enable researchers to reference glycan structures simply by accession number, as opposed to by chemical structure, which has been a burden to integrate glycomics databases in the past.

PMID:
26476458
PMCID:
PMC4702779
DOI:
10.1093/nar/gkv1041
[Indexed for MEDLINE]
Free PMC Article

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