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Arch Biochem Biophys. 2016 Jan 1;589:81-92. doi: 10.1016/j.abb.2015.10.006. Epub 2015 Oct 21.

Blood, urine and faecal metabolite profiles in the study of adult renal disease.

Author information

1
Department of Twin Research and Genetic Epidemiology, King's College London, London, UK; Department of Nephrology, Hospital del Mar. Institut Mar d'Investigacions Mediques, Barcelona, Spain.
2
Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
3
Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. Electronic address: cristina.menni@kcl.ac.uk.

Abstract

Chronic kidney disease (CKD) is a major public health burden and to date traditional biomarkers of renal function (such as serum creatinine and cystatin C) are unable to identify at-risk individuals before the disease process is well under way. To help preventive strategies and maximize the potential for effective interventions, it is important to characterise the molecular changes that take place in the development of renal damage. Metabolomics is a promising tool to identify markers of renal disease since the kidneys are involved in the handling of major biochemical classes of metabolites. These metabolite levels capture a snap-shot of the metabolic profile of the individual, allowing for the potential identification of early biomarkers, and the monitoring of real-time kidney function. In this review, we describe the current status of the identification of blood/urine/faecal metabolic biomarkers in different entities of kidney diseases including: acute kidney injury, chronic kidney disease, renal transplant, diabetic nephropathy and other disorders.

KEYWORDS:

Biomarkers; Chronic kidney disease; Metabolomics; Renal disorders

PMID:
26476344
DOI:
10.1016/j.abb.2015.10.006
[Indexed for MEDLINE]

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