Etiology and Pathogenesis of Psoriasis

Rheum Dis Clin North Am. 2015 Nov;41(4):665-75. doi: 10.1016/j.rdc.2015.07.013. Epub 2015 Sep 5.

Abstract

Psoriasis is a common, chronic inflammatory skin disease most often appearing in the form of well-demarcated, scaly plaques. These lesions highlight the fundamental processes underlying its pathogenesis, namely, inflammation and epidermal hyperproliferation. Both phenomena are considered consequences of an intimate interplay between the innate and the adaptive immune system. This concept is supported by results of genetic studies, pointing toward the signaling pathways of nuclear factor-κB, interferon-γ, and interleukin (IL)-23 as well as antigen presentation as central axes of the psoriatic inflammation. Efficacy of biologics targeting tumor necrosis factor-α, IL-23, or IL-17 provides further evidence in favor of this model.

Keywords: Dendritic cells; Etiology; Genome-wide association study; IL-17; Keratinocytes; Pathogenesis; Psoriasis; T lymphocytes.

Publication types

  • Review

MeSH terms

  • Adaptive Immunity*
  • Cytokines / metabolism*
  • Humans
  • Inflammation / metabolism*
  • Inflammation / pathology
  • Psoriasis* / etiology
  • Psoriasis* / metabolism
  • Psoriasis* / pathology
  • Skin / pathology*

Substances

  • Cytokines