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Rheum Dis Clin North Am. 2015 Nov;41(4):623-42. doi: 10.1016/j.rdc.2015.07.002. Epub 2015 Aug 24.

Genetic, Epigenetic and Pharmacogenetic Aspects of Psoriasis and Psoriatic Arthritis.

Author information

1
Faculty of Medicine, Health Sciences Centre, Memorial University of Newfoundland, 300 Prince Philip Drive, Room 1J440, St. John's, Newfoundland and Labrador A1B 3V6, Canada.
2
St. Clare's Mercy Hospital, Memorial University of Newfoundland, 154 Le Marchant Road, St. John's, Newfoundland and Labrador A1C 5B8, Canada. Electronic address: prahman@mun.ca.

Abstract

There is a strong familial component to psoriatic disease as well as a complex array of genetic, immunologic, and environmental factors. The dominant genetic effect is located on chromosome 6p21.3 within the major histocompatibility complex region, accounting for one-third of genetic contribution. Genome-wide association studies (GWAS) identified additional genes, including skin barrier function, innate immune response, and adaptive immune response genes. To better understand disease susceptibility and progression requires replication in larger cohorts, fine-mapping efforts, new technologies, and functional studies of genetic variants, gene-gene interactions and gene-environmental interactions. New technologies available include next-generation sequencing, copy number variation analysis, and epigenetics.

KEYWORDS:

Candidate genes; Epigenetics; GWAS; Genetics; Pharmacogenetics; Psoriasis; Psoriatic arthritis

PMID:
26476223
DOI:
10.1016/j.rdc.2015.07.002
[Indexed for MEDLINE]

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