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Genome Biol Evol. 2015 Oct 15;7(11):3062-9. doi: 10.1093/gbe/evv198.

Genome Sequencing of Multiple Isolates Highlights Subtelomeric Genomic Diversity within Fusarium fujikuroi.

Author information

1
Department of Biosciences, University of Milan, Italy Institute of Biomembranes and Bioenergetics, National Research Council, Bari, Italy.
2
Institute of Sciences of Food Production, National Research Council, Bari, Italy.
3
Institute of Biomembranes and Bioenergetics, National Research Council, Bari, Italy Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Italy National Institute of Biostructures and Biosystems (INBB), Rome, Italy Center of Excellence in Comparative Genomics, University of Bari, Italy.
4
Department of Plant Pathology, Kansas State University, Manhattan.
5
Department of Biosciences, University of Milan, Italy david.horner@unimi.it matteo.chiara@unimi.it toomajia@k-state.edu.

Abstract

Comparisons of draft genome sequences of three geographically distinct isolates of Fusarium fujikuroi with two recently published genome sequences from the same species suggest diverse profiles of secondary metabolite production within F. fujikuroi. Species- and lineage-specific genes, many of which appear to exhibit expression profiles that are consistent with roles in host-pathogen interactions and adaptation to environmental changes, are concentrated in subtelomeric regions. These genomic compartments also exhibit distinct gene densities and compositional characteristics with respect to other genomic partitions, and likely play a role in the generation of molecular diversity. Our data provide additional evidence that gene duplication, divergence, and differential loss play important roles in F. fujikuroi genome evolution and suggest that hundreds of lineage-specific genes might have been acquired through horizontal gene transfer.

KEYWORDS:

comparative genomics; mycotoxin; secondary metabolites

PMID:
26475319
PMCID:
PMC5635591
DOI:
10.1093/gbe/evv198
[Indexed for MEDLINE]
Free PMC Article

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