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Exp Cell Res. 1989 Apr;181(2):305-16.

The molecular basis of mutations induced by deoxyribonucleoside triphosphate pool imbalances in mammalian cells.

Author information

1
Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Hertfordshire, United Kingdom.

Abstract

Alterations of the balanced supply of the precursors of DNA synthesis, the deoxyribonucleoside triphosphates, have dramatic genetic consequences for mammalian cells including the induction of mutations, the sensitization to DNA damaging agents, and the production of gross chromosomal abnormalities. The use of recombinant DNA techniques has allowed the analysis of some of these effects and has revealed further mechanisms by which mammalian cells control the accuracy of DNA replication.

PMID:
2647496
DOI:
10.1016/0014-4827(89)90090-6
[Indexed for MEDLINE]

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