Format

Send to

Choose Destination
See comment in PubMed Commons below
J Vet Intern Med. 2015 Nov-Dec;29(6):1479-87. doi: 10.1111/jvim.13639. Epub 2015 Oct 16.

Comparison of Efficacy of Long-term Oral Treatment with Telmisartan and Benazepril in Cats with Chronic Kidney Disease.

Author information

1
Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, Germany.
2
Department of Comparative Biomedical Sciences, Royal Veterinary College, London, UK.
3
Department of Clinical Sciences and Services, Royal Veterinary College, Herts, UK.
4
Boehringer Ingelheim Animal Health GmbH, Ingelheim, Germany.

Erratum in

Abstract

BACKGROUND:

The efficacy and benefits of telmisartan in cats with chronic kidney disease (CKD) have not previously been reported.

HYPOTHESIS:

Long-term treatment of cats with CKD using telmisartan decreases urine protein-to-creatinine ratio (UP/C) similar to benazepril.

ANIMALS:

Two-hundred and twenty-four client-owned adult cats with CKD.

METHODS:

Prospective, multicenter, controlled, randomized, parallel group, blinded clinical trial with noninferiority design. Cats were allocated in a 1:1 ratio to either telmisartan (1 mg/kg; n = 112) or benazepril (0.5-1.0 mg/kg; n = 112) PO q24 h. The primary endpoint was prospectively defined as the change in proteinuria (benazepril:telmisartan) based on a log transformed weighted average of UP/C change from baseline (AUC 0→t/t) as a percentage compared using a confidence interval (CI) approach. Changes of UP/C from baseline were assessed on all study days and corrected for multiple comparisons.

RESULTS:

Telmisartan proved noninferior to benazepril in controlling proteinuria (CI, -0.035 to 0.268). At Day 180, UP/C compared to baseline in the telmisartan group was significantly lower (-0.05 ± 0.31; P = .016), whereas in the benazepril group the change (-0.02 ± 0.48) was not statistically significant (P = .136). Similar results were obtained at all assessment points with significant decrease in UP/C occurring with telmisartan but not benazepril.

CONCLUSION AND CLINICAL IMPORTANCE:

Both telmisartan and benazepril were well tolerated and safe. Telmisartan proved to be noninferior to benazepril and significantly decreased proteinuria relative to baseline at all assessment points whereas benazepril did not.

KEYWORDS:

ACE inhibitor; Angiotensin II receptor blocker; Benazepril; Proteinuria

PMID:
26474314
PMCID:
PMC4895689
DOI:
10.1111/jvim.13639
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Support Center