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Proteins. 2016 Sep;84 Suppl 1:34-50. doi: 10.1002/prot.24942. Epub 2015 Nov 16.

Some of the most interesting CASP11 targets through the eyes of their authors.

Author information

1
Genome Center, University of California, Davis, California, 95616.
2
Department of Cell Biology and Molecular Genetics, Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland, 20850.
3
Institute for Cell and Molecular Biosciences, University of Newcastle, Newcastle upon Tyne, NE2 4HH, United Kingdom.
4
Broad Institute, Cambridge, Massachusetts, 02142.
5
TimPharma, Santa Clarita, California, 91350.
6
Department of Biology, San Diego State University, San Diego, California, 92182.
7
Department of Computer Science, San Diego State University, San Diego, California, 92182.
8
Department of Structural Biology, Weizmann Institute of Science, Rehovot, 76100, Israel.
9
Department of Protein Evolution, Max Planck Institute for Developmental Biology, Tübingen, 72076, Germany.
10
Beryllium, Bainbridge Island, Washington D.C, 98110.
11
Biomedical Manufacturing Program, CSIRO, Parkville, VIC, Australia.
12
Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, 21201.
13
Department of Biochemistry and Redox Biology Center, University of Nebraska-Lincoln, Lincoln, Nebraska, 68588.
14
Centro Nactional De Biotecnologia (CNB-CSIC), Madrid, E-28049, Spain.
15
Department of Biology and Viral Information Institute, San Diego State University, San Diego, California, 92182.
16
Human Longevity Inc, La Jolla, California, 92121.
17
Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, 21201.
18
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, 21201.
19
School of Biosciences, University of Kent, Canterbury, Kent, United Kingdom.
20
Biozentrum, University of Basel, Basel, 4056, Switzerland. Torsten.Schwede@unibas.ch.
21
SIB Swiss Institute of Bioinformatics, Basel, 4056, Switzerland. Torsten.Schwede@unibas.ch.

Abstract

The Critical Assessment of protein Structure Prediction (CASP) experiment would not have been possible without the prediction targets provided by the experimental structural biology community. In this article, selected crystallographers providing targets for the CASP11 experiment discuss the functional and biological significance of the target proteins, highlight their most interesting structural features, and assess whether these features were correctly reproduced in the predictions submitted to CASP11. Proteins 2016; 84(Suppl 1):34-50. © 2015 The Authors. Proteins: Structure, Function, and Bioinformatics Published by Wiley Periodicals, Inc.

KEYWORDS:

CASP; NMR; X-ray crystallography; protein structure prediction

PMID:
26473983
PMCID:
PMC4834066
DOI:
10.1002/prot.24942
[Indexed for MEDLINE]
Free PMC Article

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