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J Acquir Immune Defic Syndr. 2015 Nov 1;70(3):236-41. doi: 10.1097/QAI.0000000000000741.

Brief Report: Coordinated Modulation of Circulating miR-21 in HIV, HIV-Associated Pulmonary Arterial Hypertension, and HIV/Hepatitis C Virus Coinfection.

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*Division of Cardiology and Center of Excellence in Vascular Research, San Francisco General Hospital, University of California, San Francisco, San Francisco, CA; †Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; ‡Divisions of Pulmonology and Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; and §Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.


Dysregulation of microRNA-21 (miR-21) is independently associated with HIV infection, pulmonary arterial hypertension (PAH), and hepatitis C virus (HCV) infection. To assess the expression of miR-21 in these overlapping comorbidities, we measured plasma miR-21 in HIV with and without PAH and then stratified by concomitant HCV infection. MiR-21 was increased in HIV and HIV-PAH versus uninfected subjects, but it did not differ between these groups. HIV/HCV coinfection correlated with even higher miR-21 levels within the HIV-infected population. These data reveal specific regulation of plasma miR-21 in HIV, HIV/HCV coinfection, and PAH and suggest that miR-21 may integrate complex disease-specific signaling in the setting of HIV infection.

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