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Elife. 2015 Oct 16;4. pii: e07903. doi: 10.7554/eLife.07903.

A nap to recap or how reward regulates hippocampal-prefrontal memory networks during daytime sleep in humans.

Author information

1
Department of Neuroscience, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
2
Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland.
3
Geneva Neuroscience Center, University of Geneva, Geneva, Switzerland.

Abstract

Sleep plays a crucial role in the consolidation of newly acquired memories. Yet, how our brain selects the noteworthy information that will be consolidated during sleep remains largely unknown. Here we show that post-learning sleep favors the selectivity of long-term consolidation: when tested three months after initial encoding, the most important (i.e., rewarded, strongly encoded) memories are better retained, and also remembered with higher subjective confidence. Our brain imaging data reveals that the functional interplay between dopaminergic reward regions, the prefrontal cortex and the hippocampus contributes to the integration of rewarded associative memories. We further show that sleep spindles strengthen memory representations based on reward values, suggesting a privileged replay of information yielding positive outcomes. These findings demonstrate that post-learning sleep determines the neural fate of motivationally-relevant memories and promotes a value-based stratification of long-term memory stores.

KEYWORDS:

fMRI; hippocampus; human; memory consolidation; neural replay; neuroscience; reward; sleep spindles

PMID:
26473618
PMCID:
PMC4721959
DOI:
10.7554/eLife.07903
[Indexed for MEDLINE]
Free PMC Article

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