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PLoS One. 2015 Oct 16;10(10):e0140883. doi: 10.1371/journal.pone.0140883. eCollection 2015.

Maintenance of Chronic Fatigue Syndrome (CFS) in Young CFS Patients Is Associated with the 5-HTTLPR and SNP rs25531 A > G Genotype.

Author information

1
Dept. of Paediatrics, Akershus University Hospital, Oslo, Norway.
2
Dept. of Physical Medicine and Rehabilitation, Oslo University Hospital, Oslo, Norway; National Institute of Occupational Health, Oslo, Norway; Department of Biosciences, University of Oslo, Oslo, Norway.
3
Dept. of Anaesthesiology and Critical Care, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, Medical Faculty, University of Oslo, Oslo, Norway.
4
Dept. of Paediatrics, Lillehammer County Hospital, Lillehammer, Norway; Dept. of Paediatrics, Oslo University Hospital, Oslo, Norway.
5
Institute of Clinical Medicine, Medical Faculty, University of Oslo, Oslo, Norway; Section for Clinical Molecular Biology, Akershus University Hospital, Oslo, Norway.
6
Dept. of Paediatrics, Akershus University Hospital, Oslo, Norway; Institute of Clinical Medicine, Medical Faculty, University of Oslo, Oslo, Norway.

Abstract

Earlier studies have shown that genetic variability in the SLC6A4 gene encoding the serotonin transporter (5-HTT) may be important for the re-uptake of serotonin (5-HT) in the central nervous system. In the present study we investigated how the 5-HTT genotype i.e. the short (S) versus long (L) 5-HTTLPR allele and the SNP rs25531 A > G affect the physical and psychosocial functioning in patients with chronic fatigue syndrome (CFS). All 120 patients were recruited from The Department of Paediatrics at Oslo University Hospital, Norway, a national referral center for young CFS patients (12-18 years). Main outcomes were number of steps per day obtained by an accelerometer and disability scored by the Functional Disability Inventory (FDI). Patients with the 5-HTT SS or SLG genotype had a significantly lower number of steps per day than patients with the 5-HTT LALG, SLA or LALA genotype. Patients with the 5-HTT SS or SLG genotype also had a significantly higher FDI score than patients with the 5-HTT LALG, SLA or LALA genotype. Thus, CFS patients with the 5-HTT SS or SLG genotype had worse 30 weeks outcome than CFS patients with the 5-HTT LALG, SLA or LALA genotype. The present study suggests that the 5-HTT genotype may be a factor that contributes to maintenance of CFS.

PMID:
26473596
PMCID:
PMC4608737
DOI:
10.1371/journal.pone.0140883
[Indexed for MEDLINE]
Free PMC Article

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