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IUBMB Life. 2015 Nov;67(11):801-15. doi: 10.1002/iub.1441. Epub 2015 Oct 16.

Molecular basis of the regulation of iron homeostasis in fission and filamentous yeasts.

Author information

1
Département de Biochimie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, QC, Canada.

Abstract

When iron load exceeds that needed by fission and filamentous yeasts, iron-regulatory GATA-type transcription factors repress genes encoding iron acquisition systems. In contrast, under iron starvation, optimization of cellular iron utilization is coordinated by a specialized regulatory subunit of the CCAAT-binding factor that fosters repression of genes encoding iron-using proteins. Despite these findings, there is still limited knowledge concerning the mechanisms by which these iron-responsive regulators respond to high- or low-iron availability. To provide a framework for understanding common and distinct properties of iron-dependent transcriptional regulators, a repertoire of their functional domains in different fungal species is presented here. In addition, discovery of interacting partners of these iron-responsive factors contributes to provide additional insight into their properties.

KEYWORDS:

fungal iron-dependent CCAAT-binding factors; iron-regulatory GATA-type transcription factors; iron-sparing response; regulation of iron acquisition

PMID:
26472434
DOI:
10.1002/iub.1441
[Indexed for MEDLINE]
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