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IUBMB Life. 2015 Nov;67(11):801-15. doi: 10.1002/iub.1441. Epub 2015 Oct 16.

Molecular basis of the regulation of iron homeostasis in fission and filamentous yeasts.

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Département de Biochimie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, QC, Canada.


When iron load exceeds that needed by fission and filamentous yeasts, iron-regulatory GATA-type transcription factors repress genes encoding iron acquisition systems. In contrast, under iron starvation, optimization of cellular iron utilization is coordinated by a specialized regulatory subunit of the CCAAT-binding factor that fosters repression of genes encoding iron-using proteins. Despite these findings, there is still limited knowledge concerning the mechanisms by which these iron-responsive regulators respond to high- or low-iron availability. To provide a framework for understanding common and distinct properties of iron-dependent transcriptional regulators, a repertoire of their functional domains in different fungal species is presented here. In addition, discovery of interacting partners of these iron-responsive factors contributes to provide additional insight into their properties.


fungal iron-dependent CCAAT-binding factors; iron-regulatory GATA-type transcription factors; iron-sparing response; regulation of iron acquisition

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