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Clin Exp Rheumatol. 2015 Sep-Oct;33(5 Suppl 93):S2-6. Epub 2015 Oct 15.

Pathogenesis and treatment of psoriasis: exploiting pathophysiological pathways for precision medicine.

Author information

1
St. John's Institute of Dermatology, Guy's and St. Thomas' Hospitals NHS Foundation Trust, London, UK.
2
St. John's Institute of Dermatology, Guy's and St. Thomas' Hospitals NHS Foundation Trust, London, UK. frank.nestle@kcl.ac.uk.

Abstract

Psoriasis is a common, chronic inflammatory skin disease associated with multi-system manifestations including arthritis and obesity. Our knowledge of the aetiology of the condition, including the key genomic, immune and environmental factors, has led to the development of targeted, precision therapies that alleviate patient morbidity. This article reviews the key pathophysiological pathways and therapeutic targets and highlights future areas of interest in psoriasis research.

PMID:
26472336
[Indexed for MEDLINE]

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