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Acta Orthop. 2016 Feb;87(1):55-9. doi: 10.3109/17453674.2015.1103568. Epub 2015 Oct 16.

Antibiotic cement was associated with half the risk of re-revision in 1,154 aseptic revision total knee arthroplasties.

Author information

1
a Department of Orthopaedic Surgery , The Permanente Medical Group , Oakland , CA.
2
b Surgical Outcomes and Analysis , Kaiser Permanente , San Diego , CA , USA.
3
c Medicine and Devices Surveillance Centre of Research Excellence, School of Pharmacy and Medical Sciences, University of South Australia , Adelaide , SA , Australia.
4
d Department of Orthopaedic Surgery , Southern California Permanente Medical Group , Los Angeles , CA , USA.

Abstract

BACKGROUND AND PURPOSE:

Aseptic revisions comprise 80% of revision total knee arthroplasties (TKAs). We determined the incidence of re-revision TKA, the reasons for re-revision, and risk factors associated with these procedures.

PATIENTS AND METHODS:

We conducted a retrospective cohort study of 1,154 patients who underwent aseptic revision TKA between 2002 and 2013 and were followed prospectively by a total joint replacement registry in the USA. Revision was defined as any operation in which an implanted component was replaced. Patient-, surgeon-, and procedure-related risk factors were evaluated. Survival analyses were conducted.

RESULTS:

There were 114 re-revisions (10%) with a median time to reoperation of 3.6 years (interquartile range (IQR): 2.6-5.2). The infection rate was 2.9% (34/1,154) and accounted for 30% of re-revisions (34 of 114). In adjusted models, use of antibiotic-loaded cement was associated with a 50% lower risk of all-cause re-revision surgery (hazard ratio (HR) = 0.5, 95% CI: 0.3-0.9), age with a 20% lower risk for every 10-year increase (HR = 0.8, CI: 0.7-1.0), body mass index (BMI) with a 20% lower risk for every 5-unit increase (HR = 0.8, CI: 0.7-1.0), and a surgeon's greater cumulative experience (≥ 20 cases vs. < 20 cases) with a 3 times higher risk of re-revision (HR = 2.8, CI: 1.5-5).

INTERPRETATION:

Revised TKAs were at high risk of subsequent failure. The use of antibiotic-loaded cement, higher age, and higher BMI were associated with lower risk of further revision whereas a higher degree of surgeon experience was associated with higher risk.

PMID:
26472086
PMCID:
PMC4940593
DOI:
10.3109/17453674.2015.1103568
[Indexed for MEDLINE]
Free PMC Article

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