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J Biomed Mater Res B Appl Biomater. 2016 May;104(4):698-711. doi: 10.1002/jbm.b.33545. Epub 2015 Oct 15.

Drug-conjugated polymers as gene carriers for synergistic therapeutic effect.

Author information

1
Department of Chemical Engineering, Institute of Chemical Technology, Mumbai, 400-019, India.
2
Department of Molecular Genetics and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, 110-749, Republic of Korea.
3
Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul, 151-921, Republic of Korea.
4
Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai, 400-019, India.

Abstract

The ability to safely and effectively transfer gene into cells is the fundamental goal of gene delivery. In spite of the best efforts of researchers around the world, gene therapy has limited success. This may be because of several limitations of delivering gene which is one of the greatest technical challenges in the modern medicine. To address these issues, many efforts have been made to bind drugs and genes together by polymers for co-delivery to achieve synergistic effect. Usually, binding interaction of drugs with polymers is either physical or chemical. In case of drug-polymer physical interaction, the efficiency of drugs generally decreases because of separation of drugs from polymers in vivo whenever it comes in contact with charged biofluid/s or cells. While chemical interaction of drug-polymer overcomes the aforementioned obstacle, several problems such as steric hindrance, solubility, and biodegradability hinder it to develop as gene carrier. Considering these benefits and pitfalls, the objective of this review is to discuss the possible extent of drug-conjugated polymers as safe and efficient gene delivery carriers for achieving synergistic effect to combat various genetic disorders.

KEYWORDS:

co-delivery; combination therapy; drug conjugated polymer; gene delivery; synergism

PMID:
26471335
DOI:
10.1002/jbm.b.33545
[Indexed for MEDLINE]

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