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BMC Infect Dis. 2015 Oct 15;15:433. doi: 10.1186/s12879-015-1171-x.

Dissemination of clonal complex 2 Acinetobacter baumannii strains co-producing carbapenemases and 16S rRNA methylase ArmA in Vietnam.

Author information

1
Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Shinjuku, Tokyo, Japan. ttada@ri.ncgm.go.jp.
2
Pathogenic Microbe Laboratory, Research Institute, National Center for Global Health and Medicine, Shinjuku, Tokyo, Japan. takiyam@ri.ncgm.go.jp.
3
Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Shinjuku, Tokyo, Japan. kshima@ri.ncgm.go.jp.
4
Cho Ray Hospital, Ho Chi Minh, Vietnam. ngatrancrh@gmail.com.
5
Cho Ray Hospital, Ho Chi Minh, Vietnam. letathu@yahoo.com.
6
Cho Ray Hospital, Ho Chi Minh, Vietnam. truongson_cr@yahoo.com.vn.
7
Disease Control and Prevention Center, Division of Infectious Diseases, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku, Tokyo, 162-8655, Japan. nohmagari@hosp.ncgm.go.jp.
8
Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Shinjuku, Tokyo, Japan. tkirikae@ri.ncgm.go.jp.

Abstract

BACKGROUND:

Acinetobacter baumannii strains co-producing carbapenemase and 16S rRNA methylase are highly resistant to carbapenems and aminoglycosides.

METHODS:

Ninety-three isolates of multidrug-resistant A. baumannii were obtained from an intensive care unit in a hospital in Vietnam. Antimicrobial susceptibility tests and whole genome sequencing were performed. Multilocus sequence typing and the presence of drug resistant genes were determined and a maximum-likelihood phylogenetic tree was constructed by SNP alignment of whole genome sequencing data.

RESULTS:

The majority of isolates belonged to clonal complex 2 (ST2, ST570 and ST571), and carried carbapenemase encoding genes bla OXA-23 and bla OXA-66. Two isolates encoded carbapenemase genes bla NDM-1 and bla OXA-58 and the 16S rRNA methylase encoding gene armA and did not belong to clonal complex 2 (ST16).

CONCLUSION:

A. baumannii isolates producing 16S rRNA methylase ArmA and belonging to clonal complex 2 are widespread, and isolates co-producing NDM-1 and ArmA are emerging, in medical settings in Vietnam.

PMID:
26471294
PMCID:
PMC4608321
DOI:
10.1186/s12879-015-1171-x
[Indexed for MEDLINE]
Free PMC Article

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