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Helicobacter. 2016 Aug;21(4):266-78. doi: 10.1111/hel.12279. Epub 2015 Oct 16.

Eradication Rates of Helicobacter pylori in Korea Over the Past 10 years and Correlation of the Amount of Antibiotics Use: Nationwide Survey.

Author information

1
Department of Internal Medicine, Hallym University College of Medicine, Seoul, Korea.
2
Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
3
Department of Internal Medicine, Konyang University College of Medicine, Daejeon, Korea.
4
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
5
Department of Internal Medicine, Gachon University College of Medicine, Incheon, Korea.
6
Department of Internal Medicine and Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, Korea.
7
Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.
8
Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea.
9
Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea.
10
Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
11
Department of Internal Medicine, Inje University College of Medicine, Busan, Korea.
12
Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea.
13
Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
14
Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, Korea.
15
Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
16
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
17
Department of Internal Medicine, Chonnam National University School of Medicine, Gwangju, Korea.
18
Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, Korea.
19
Department of Finance and Information Statistics, Hallym University College of Natural Science, Chuncheon, Korea.
20
Medical Research Collaborating Center, Seoul National University Hospital, Seoul, Korea.
21
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
22
Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
23
Department of Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea.

Abstract

BACKGROUND:

The efficacy of proton-pump inhibitor-amoxicillin-clarithromycin therapy for H. pylori eradication has decreased over time.

OBJECTIVE:

We assessed the trend of H. pylori eradication rates over the last 10 years and the relationship between the eradication rates and the amount of macrolide antibiotic use in a country with a high prevalence of H. pylori infection.

METHODS:

This vast nationwide multicenter study was conducted with 34,139 adults treated for H. pylori infection from January 2001 to December 2010. The defined daily dose per km(2) (DSD) of macrolide antibiotics was calculated (n = 141,019) using the Health Insurance Review & Assessment data base from 2008 to 2010 in the two cities which had the lowest (Jeju city) or highest (Chuncheon city) eradication rate.

RESULTS:

The eradication rates of proton-pump inhibitor-amoxicillin-clarithromycin therapy ranged 84.9-87.5% from 2001 to 2007, and those of 2008 to 2010 ranged 80.0-81.4% with a decreasing trend (p < 0.0001). The decreasing trend of eradication rates for the overall first-line therapy was observed only in three of the seven geographic areas in Korea (p < 0.0001). The DSD of macrolide antibiotics was significantly higher in Jeju than Cheunchon city (0.85 vs 0.52, p < 0.0001).

CONCLUSIONS:

H. pylori eradication rates with clarithromycin-containing triple therapy in Korea showed a decreasing trend over the past 10 years, although the trend varied among geographic areas. This difference may be associated with the amount of macrolide antibiotic use.

KEYWORDS:

Helicobacter pylori; antibiotics; treatment failure; trends

PMID:
26470999
DOI:
10.1111/hel.12279
[Indexed for MEDLINE]

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