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Opt Lett. 2015 Oct 15;40(20):4803-6. doi: 10.1364/OL.40.004803.

High-throughput optofluidic particle profiling with morphological and chemical specificity.


We present a method for high-throughput optofluidic particle analysis that provides both the morphological and chemical profiles of individual particles in a large heterogeneous population. This method is based on an integration of a time-stretch optical microscope with a submicrometer spatial resolution of 780 nm and a three-color fluorescence analyzer on top of an inertial-focusing microfluidic device. The integrated system can perform image- and fluorescence-based screening of particles with a high throughput of 10,000 particles/s, exceeding previously demonstrated imaging particle analyzers in terms of specificity without sacrificing throughput.

[Indexed for MEDLINE]

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