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Cell Host Microbe. 2015 Oct 14;18(4):395-7. doi: 10.1016/j.chom.2015.10.003.

The Quest for a Universal Flu Vaccine: Headless HA 2.0.

Author information

1
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: florian.krammer@mssm.edu.

Abstract

Two recent publications report the design of immunogens based on the conserved stalk domain of the influenza virus hemagglutinin. These new "headless" hemagglutinin constructs recapitulate the epitopes recognized by broadly neutralizing antibodies and induce broadly protective/heterosubtypic immunity in animal models, bringing us a step closer to "universal" influenza virus vaccines.

PMID:
26468743
DOI:
10.1016/j.chom.2015.10.003
[Indexed for MEDLINE]
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