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Expert Rev Vaccines. 2015;14(12):1525-7. doi: 10.1586/14760584.2015.1096781. Epub 2015 Oct 15.

Malaria vaccine based on self-assembling protein nanoparticles.

Author information

  • 1a Institute of Materials, Science and Department of Molecular and Cell Biology , University of Connecticut , Storrs , CT 06269 , USA.
  • 2b Malaria Vaccine Branch , Walter Reed Army Institute of Research , Silver Spring , MD 20910 , USA.

Abstract

Despite recent progress with GSK's RTS,S malaria vaccine, there remains a desperate need for an efficient malaria vaccine. We have used a repetitive antigen display technology to display malaria specific B cell and T cell epitopes in an effort to design a vaccine against Plasmodium falciparum malaria. Our protein sequence when assembled into a nanoparticle induces strong, long-lived and protective immune responses against infection with the parasite. We are confident that the clinical trials with our most developed vaccine candidate will show good protection in a controlled human malaria infection trial.

KEYWORDS:

Plasmodium falciparum; SAPN; malaria; nanoparticle; vaccine

PMID:
26468608
PMCID:
PMC5019124
DOI:
10.1586/14760584.2015.1096781
[PubMed - indexed for MEDLINE]
Free PMC Article
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