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J Virol. 2015 Oct 14;90(1):605-10. doi: 10.1128/JVI.01828-15. Print 2016 Jan 1.

Ebolavirus Glycoprotein Directs Fusion through NPC1+ Endolysosomes.

Author information

1
Department of Cell Biology, University of Virginia, Charlottesville, Virginia, USA.
2
Department of Pharmacology, University of Oxford, Oxford, United Kingdom.
3
Department of Cell Biology, University of Virginia, Charlottesville, Virginia, USA jw7g@virginia.edu.

Abstract

Ebolavirus, a deadly hemorrhagic fever virus, was thought to enter cells through endolysosomes harboring its glycoprotein receptor, Niemann-Pick C1. However, an alternate model was recently proposed in which ebolavirus enters through a later NPC1-negative endosome that contains two-pore Ca(2+) channel 2 (TPC2), a newly identified ebolavirus entry factor. Here, using live cell imaging, we obtained evidence that in contrast to the new model, ebolavirus enters cells through endolysosomes that contain both NPC1 and TPC2.

PMID:
26468524
PMCID:
PMC4702577
DOI:
10.1128/JVI.01828-15
[Indexed for MEDLINE]
Free PMC Article

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