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Semin Immunopathol. 2016 May;38(3):309-19. doi: 10.1007/s00281-015-0535-z. Epub 2015 Oct 14.

Transient Receptor Potential (TRP) channels in T cells.

Author information

1
Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0663, USA. sbertin@ucsd.edu.
2
Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0663, USA.

Abstract

The transient receptor potential (TRP) family of ion channels is widely expressed in many cell types and plays various physiological roles. Growing evidence suggests that certain TRP channels are functionally expressed in the immune system. Indeed, an increasing number of reports have demonstrated the functional expression of several TRP channels in innate and adaptive immune cells and have highlighted their critical role in the activation and function of these cells. However, very few reviews have been entirely dedicated to this subject. Here, we will summarize the recent findings with regards to TRP channel expression in T cells and discuss their emerging role as regulators of T cell activation and functions. Moreover, these studies suggest that beyond their pharmaceutical interest in pain management, certain TRP channels may represent potential novel therapeutic targets for various immune-related diseases.

KEYWORDS:

Ca2+ signaling; T cell receptor; T cells; TRP channels

PMID:
26468011
PMCID:
PMC4833713
DOI:
10.1007/s00281-015-0535-z
[Indexed for MEDLINE]
Free PMC Article

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